个人简介

 

工作单位：澳门永利最新登录网址/澳门永利最新登录网址

单位地址：昆明市呈贡区大学城东外环南路

邮 编：650500

电子邮箱：jwsun@ynu.edu.cn

一、 个人情况介绍

博士、教授、博士生导师。2021年入选云南省杰出青年基金项目资助。中国生物物理学会线粒体分会理事，以通讯/第一作者身份在Journal of Cell Biology、Oncogene、Journal of Biological Chemistry、Journal of cell science等国际一流学术期刊发表近20篇。

二、 教育经历

2006.09-2010.11   中国科学院遗传发育所 博士

2003.09-2006.07   青岛农业大学   硕士

1999.09-2003.07   青岛农业大学   学士

三、 工作经历

2019.01-至今 澳门永利最新登录网址 澳门永利最新登录网址 教授 博士生导师

2015.05 -2018.12   华南农业大学 澳门永利最新登录网址 教授   博士生导师

2014.12 -2015.04   Moffitt癌症研究中心 研究科学家

2010.12 -2014.11   Moffitt癌症研究中心 博士后

四、研究方向

1． 钙池操纵的钙内流（SOCE）调控癌症发生及转移的分子机制

2． 肿瘤抗药性的机制研究

3． 线粒体功能调控失调在肿瘤发生中作用及机制

五、实验室成员

博士生：桑磊（获2021年云南省奖学金），郝庆刚，刘享享，白韦钰。

硕士生：严程浩，董瑞，陆梅，韩冰心，韩荣琳，常栋，邱少卿

已毕业研究生：

博士生：康嘉欣（获2018年国家奖学金）

硕士生：白韦钰，商荣磊，孙瑞，胡元昭，许安祺

六、研究论文（*通讯作者)

1. Junling Shen, Jilong Yang, Rui Sun, Lei Sang, Weiyu Bai, Chao Wang, Yan Sun, Jianwei Sun*. BRAF V600E inhibitor vermurafenib induced melanoma cell invasion by activating STIM1- Pyk2 signaling axis and promoting invadopodia formation. Cancer Biology and Medicine. (2021, in press)

2. Lei Sang, Ying-jie He, Jiaxin Kang, Hongyi Ye, Weiyu Bai, Xiao-dong Luo and Jianwei Sun*. Mitochondrial deoxyguanosine kinase (DGUOK) regulates NAD+ Biogenesis Independent of mitochondria complex I activity. Frontiers in Oncology 2020 Dec 18;10:570656. doi: 10.3389/fonc.2020.570656

3. 桑磊，董瑞，陆梅，孙建伟*  Fascin：恶性肿瘤不良预后标志. 现代肿瘤医学. 2021

4. 孙瑞, 胡元昭, 商荣磊, 白韦钰 孙建伟*. 线粒体脱氧鸟苷激酶在肺癌肿瘤发生中的作用及机制研究 (中国科学：生命科学) . 2019, 49(7): 893-901

5. Jian Wang, Junling Shen, Kaili Zhao, Jinmeng Hu, Jiuxing Dong, Yan Sun and Jianwei Sun*. STIM1 overexpression in hypoxia microenvironment contributes to pancreatic carcinoma progression. Cancer Biology and Medicine. 2019 Feb;16(1):100-108. doi: 10.20892/j.issn.2095-3941.2018.0304

6. Fujian Lu^#, Jianwei Sun^#, Qiaoxia Zheng, Jinghang Li, Yuanzhao Hu, Peng Yu, Huifang He, Yan Zhao, Xianhua Wang, Shengyu Yang* and Heping Cheng*. Imaging elemental events of store-operated Ca2+ entry in invading cancer cells with plasmalemmal targeted sensors. Journal of Cell Science (2019) 132, jcs224923. doi:10.1242/jcs.224923.

7. Jiaxin Kang, Jian Wang, Zhuang Yao, Yuanzhao Hu, Shijie Ma，Qin Fan，Yan Sun^* and Jianwei Sun*. Fascin induce melanoma tumorgenesis and stemness through regulating TAZ stability. Cell Communication & Signaling. 2018 Jul 3;16(1):37. doi: 10.1186/s12964-018-0250-1.

8. Shengchen Lin^#, Shuang Lu^#, Mentor Mulaj, Bin Fang, Tyler Keeley, Lixin Wan, Jihui Hao, Martin Muschol, Jianwei Sun* and Shengyu Yang*. Monoubiquitination Inhibits the Actin Bundling Activity of Fascin . Journal of Biological Chemistry. 2016 Dec 30;291(53):27323-27333.(*共同通讯作者)

9. Jaw-Yuan Wang^#, Jianwei Sun^#, Ming-Yii Huang, Ming-Feng Hou, Yu-Shiuan Wang, Yan Sun, Yao-Ting Tsai, Huifang He, Shengchen Lin, Shengyu Yang, and Wei-Chiao Chang.  STIM1 Overexpression promoted Colorectal Cancer Progression, Cell Motility and COX-2 Expression. (#共同第一作者) Oncogene, 2015 Aug 13;34(33):4358-67.

10. Jianwei Sun, Shengchen Lin, Tyler S Keeley, Shengyu Yang. Disseminating Melanoma Cells Surf on Calcium Waves. Molecular & Cellular Oncology. 2015;2(4). pii: e1002714

11. Jianwei Sun, Fujian Lu, Huifang He, Junling Shen, Jane Messina, Rahel Mathew, Dapeng Wang, Amod A. Sarnaik, Wei-Chiao Chang, Minjung Kim, Heping Cheng, and Shengyu Yang. STIM1- and Orai1-mediated Ca2+ oscillation orchestrates invadopodium formation and melanoma invasion. Journal of Cell Biology. 2014 Nov 24, 207(4): 535-548. (Highlighted by JCB editor: http://jcb.rupress.org/content/early/2014/11/10/jcb.2074iti3)

12. Jianwei Sun, Huifang He, Smitha Pillai, Yin Xiong, Sridevi Challa, Liyan Xu, Srikumar Chellappan and Shengyu Yang. GATA3 Transcription Factor Abrogates Smad4 Transcription Factor-mediated Fascin Overexpression, Invadopodium Formation, and Breast Cancer Cell Invasion. Journal of Biological Chemistry. 2013 Dec 27;288(52):36971-82.

13. Jianwei Sun, Huifang He, Yin Xiong, Shuang Lu, Junling Shen, Anna Cheng, Wei-Chiao Chang,Ming-Feng Hou, Johnathan M. Lancaster, Minjung Kim and Shengyu Yang. Fascin Protein Is Critical for Transforming Growth Factor Protein-induced Invasion and Filopodia Formation in Spindle-shaped Tumor Cells. Journal of Biological Chemistry 2011, 286(45): 38865–38875.

14. Mei Yang^#, Jianwei Sun^#, Xiaojuan Sun, Qinfang Shen, Zhiyang Gao and Chonglin Yang. Caenorhabditis elegans Protein Arginine Methyltransferase PRMT-5 Negatively Regulates DNA Damage-induced Apoptosis. PLoS Genetics 2009 5(6):e1000514. (#共同第一作者)